Contract Manufacturing

Cipla Medpro Manufacturing (CMM)

Bringing world class, flexible, contract manufacturing solutions to South Africa.

Situated in Durban, Cipla Medpro Manufacturing (Pty) Ltd is one of South Africa's largest pharmaceutical manufacturing plants, approved by the SA Medicines Control Council (MCC), and headed by a strong, experienced management team.

CMM is fully equipped to offer local and multinational pharmaceutical companies world class, high volume contract manufacturing solutions in line with MCC cGMP (current Good Manufacturing Practice) and PIC/S standards.

CMM is also one of only two facilities in South Africa offering manufacturing capability for effervescent formulations.

Through its close association with Cipla India, experts in pharmaceutical manufacturing to globally accredited standards for over 75 years, CMM benefits from their manufacturing expertise and customers are assured the benefit of our competitive advantage and strong buying power when sourcing raw materials.

Unique design and capabilities, from start to finish.
The facility is uniquely designed in that there is physical segregation between stores, primary and secondary processing areas. This minimises the risk of contamination and ensures material flow is uni-directional. All incoming materials are received in accordance to cGMP principles and are housed in dedicated warehouses i.e. primary, secondary etc. Warehouses, including the finished goods store, are temperature and humidity controlled in accordance with required material storage conditions.

CMM currently offers:

• Four dispensaries each with uni-directional airflow units designed to protect the operator and product from exposure during dispensing activities;
• Three granulation suites equipped with a range of granulators and driers;
• One blending room for mixing powders and granules;
• Compression and encapsulation departments equipped with state of the art machines;
• Coating suites with state of the art coaters. Two high-tech coaters are capable of coating large batch sizes in optimum time. Coating capabilities include solvent, aqueous and sugar coating.
• A fully validated, computerised maintenance system is in place to ensure that all preventive maintenance and calibrations are done in a systematic, electronic and optimal format, thus significantly reducing potential for human error. This capability is unique in the local pharmaceutical manufacturing environment.
• New stability chambers

Further improvements undertaken are:

• A major upgrade of the Quality Control Laboratory and the Microbiology Laboratory
• Modern high tech equipment for the prodution areas

Dedicated Tech Transfer team:
As a contract manufacturer, CMM recognises the importance of having a skilled, experienced and efficient team involved in the introduction of new products into the facility. As such, a dedicated technology transfer team comprising technology transfer pharmacists, laboratory personnel and a project co-ordinator facilitate the smooth introduction of new products into the facility, in accordance with cGMP requirements.

Experienced management and full systems support ensures peace of mind:
CMM's 300-strong staff complement (including contract and temporary staff) is headed by a strong management team experienced in international manufacturing practices. A full engineering support team is on site to maintain the state of the art equipment and ensure continuous machine operation and minimize downtimes through an extensive preventive maintenance program.

A highly skilled team of qualified professionals across all areas and departments ensure that quality assurance, quality systems, technology transfer and manufacturing processes are maintained at international standards.

Capabilities:
The following range of products can currently be manufactured:

• Tablets (un-coated or film/sugar coated)
• Capsules
• Powders
• Effervescent powders and granules

Processes:

• Dry blending/ Direct compression
• Wet granulation aqueous /non-aqueous (vertical granulators, planetary mixers , FBE's)
• Conventional tray drying
• Fluid-bed drying
• Tabletting
• Encapsulation
• Aqueous or solvent based film coating
• Effervescent manufacturing and packing

Packaging:

• Blister (PVC or PVC/PVDC; ALU/ALU)
• Sachets (granules/powder)
• Glass bottles (granules/powder)
• Bulk packaging
• Tablet container packaging
• Effervescent packaging
• Patient ready zip packs